Antifungal and probiotics could be very effective in Crohn's disease

Crohn's disease is a chronic autoimmune disorder characterized by the presentation of ulcers or fistulas in the digestive tract, especially in the small intestine. A disease, ulcerative colitis with equally-characterized by ulceration and inflammation, in this case in the wall of the colon Colon, is presented as the most common inflammatory bowel disease (IBD) and 45,000 suffering Spanish. And a disease that also is very difficult to treat. In fact, treatment with immunosuppressive drugs just do not work in most patients, where the disease has just obstructing intestine and should be resorted to surgery. Hence the importance of a new study led by researchers at Case Western Reserve University in Cleveland (USA), which shows that the fungi that inhabit the gastrointestinal tract also play an important role in the appearance and progression of Crohn's disease and, therefore, it suggests that the use of antifungals and probiotics could be very effective in improving the symptoms of patients. As Mahmoud A. Ghannoum, director of the research published in the journal "Digestive and Liver Disease," "Unfortunately, most of the work carried out on microorganisms of the gastrointestinal tract explains have focused on the exclusive study of bacteria and they have omitted one of the protagonists: fungi. Therefore, and in order to alleviate this situation, we have focused our efforts on the study of fungal community residing in the gastrointestinal tract. A community known as' micobioma ''. Bacterioma and micobioma The new study is the first conducted to date to jointly analyze both the bacteria-or 'bacterioma'- as the fungal community -o' micobioma'- the gastrointestinal tract in patients with Crohn's disease and their healthy relatives. Reminds Mahmoud Ghannoum, "the gastrointestinal tract of humans is home to trillions of microorganisms, some beneficial and other potentially harmful. And in this context, recent advances have allowed us to identify a multitude of organisms that inhabit the gastrointestinal tract and analyze those who play a role in inflammatory bowel disease. " The gastrointestinal tract of humans is home trillion microorganismosMahmoud Ghannoum The results showed that patients with Crohn's disease have, compared to their healthy relatives, an imbalance in the concentration of two bacterial species-specifically, of 'Serratia marcescens' and 'Escherichia coli'- and a fungus called "Candida tropicalis". And also, and more importantly, these three organisms cooperate in the formation of biofilms capable exacerbate intestinal inflammation. As mentioned by the authors, "although the relationship between bacteria and fungi already been recognized are not the intestinal tract, but throughout the body, our work is the first to show that bacteria and fungi ' they work 'together to exacerbate inflammatory symptoms in Crohn's disease. Thus, our results provide insight into the role of different microorganisms in Crohn's disease and open the door to the development of new diagnostic tests and treatments for this disease and other digestive diseases. " And exactly therapeutic applications, what would these potential treatments? So basically, and as the authors themselves suggest, the use of antifungals and probiotics specifically designed to balance the concentrations of bacteria and fungi and destroy biofilms digestive plate. Thus, and as antifungals avoid the uncontrolled growth of fungi, probiotics that is, foods containing live microorganisms with activity intestinal- help restore and maintain the balance of the microbiota, or what is the same, the bacterioma and micobioma. As concluded by Mahmoud Ghannoum, "our groundbreaking discovery, which shows that both bacteria and fungi play a critical role in health and disease, has enormous implications not only for understanding the disease process, but also for the development of treatments that, potentially, change the lives of patients suffering from chronic digestive diseases. "


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